肥胖糖尿病中異位脂肪堆積的新視角

New Perspective of Ectopic Fat Accumulation in Diabesity

全球肥胖盛行率持續攀升，已成為重大公共衛生議題，並與第2型糖尿病、心血管疾病、多種癌症等共病症及高死亡風險密切相關。脂肪組織，尤其是內臟脂肪，其分布位置比總量更能預測代謝危害。當皮下脂肪儲存能力飽和時，多餘脂肪會「溢出」，並異位堆積於肝臟、胰臟、腎臟和心臟，引發這些器官的炎症、功能異常，進而導致胰島素抵抗、器官損傷及相關疾病進展。因此，須深入理解異位脂肪堆積的機制及其對各器官的影響，對於發展精準的預防和治療策略，以應對日益嚴峻的全球肥胖挑戰。

Global obesity prevalence continues to rise, becoming a major public health issue closely linked to comorbidities like type 2 diabetes, cardiovascular diseases, and various cancers, significantly increasing the risk of mortality. Adipose tissue, particularly visceral fat, predicts metabolic harm more effectively by its distribution than by its total amount. When subcutaneous fat storage capacity is saturated, excess fat ''spills over'' and accumulates ectopically in organs such as the liver, pancreas, kidneys, and heart, triggering inflammation and dysfunction in these organs, which in turn leads to insulin resistance, organ damage, and the progression of related diseases. Therefore, a deep understanding of the mechanisms of ectopic fat deposition and its effects on various organs is crucial for developing precise prevention and treatment strategies to address the increasingly severe global challenge of obesity.