| 英文摘要 |
A series of chromatographic separation on the liquid-state fermented products of Didymocyrtis brachylaenae Km1530 derived from the littoral medicinal herb Atriplex maximowicziana Makino, resulted in the isolation of compounds 1—13. Their structures were determined by spectroscopic analysis as five previously unreported C13 polyketides, namely brachylactones A—D (1—4) and brachic acid (5), along with eight known compounds 6—13. Among these, brachylactones A (1) and B (2) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-induced murine BV- 2 microglial cells at a concentration of 20μM without any cytotoxicity. |
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