中藥治療接受抗賀爾蒙療法乳癌患者牙周病之病例報告及文獻回顧

Herbal Medicine (Traditional Chinese Medicine) Treatment for Periodontal Disease in Breast Cancer Patients Undergoing Antihormonal Therapy: A Case Report and Literature Review

癌症已成為國人十大死因之首。研究顯示，乳癌治療中的抗賀爾蒙療法可能引發齒槽骨退縮、牙齦疼痛及發炎等問題，嚴重時甚至可能影響乳癌的發生與轉移，因此需要積極處理。本病例報告一位64歲女性患者，在乳癌治療期間出現牙齦腫痛及出血，經牙科常規治療後，症狀未見改善；經中醫診斷為胃火上蒸、氣血不足、氣滯血瘀等證型，並開立濃縮中藥製劑治療，症狀獲得有效改善。回顧相關資料，乳癌後使用抗賀爾蒙療法的副作用及治療雖有許多文獻，但對其所引發牙周病的討論卻不多，牙周病不只影響口腔健康，也會增加如心血管、代謝、自體免疫疾病等風險，甚至有可能影響乳癌預後，乳癌患者常因疾病狀況無法接受及時治療，故藉此個案分享中醫治療乳癌後荷爾蒙治療所引發的牙周疾病的療效及思路。

Cancer has become the leading cause of death in our country. Studies show that antihormonal therapy in breast cancer treatment may cause dental issues such as alveolar bone resorption, gum pain, and inflammation. In severe cases, dental issues can even increase the risk of developing cancer and metastasis of breast cancer, requiring active management. This case report presents a 64-year-old female patient who developed gum swelling, pain, and bleeding during breast cancer treatment. After routine dental treatment, her symptoms showed no improvement. Traditional Chinese Medicine (TCM) diagnosed her with syndromes of Stomach Fire, Qi and Blood Deficiency, Qi Stagnation, and Blood Stasis, and a concentrated herbal formula was prescribed, resulting in significant symptom improvement. A review of relevant literature reveals many studies on the side effects and treatments of antihormonal therapy following breast cancer; however, there is limited discussion on the periodontal diseases induced by this therapy. This case aims to share the effectiveness and approach of TCM in treating periodontal diseases induced by post-breast cancer hormonal therapy.