探討不同試劑廠牌低密度脂蛋白膽固醇測量對臨床決策值的影響

Explore the Impact of Low Density Lipoprotein-Cholesterol Measurement on Clinical Decision-Making Values from Different Reagent Manufacturers

本研究探討Kyowa及Sekisui兩種不同試劑廠牌測定原理，對於低密度脂蛋白膽固醇(Low Density Lipoprotein-Cholesterol；LDL-C)的檢測差異性。實驗結果顯示在體檢族群及新陳代謝科病人族群中使用Kyowa試劑檢測出的LDL-C結果皆高於Sekisui試劑，且在不同族群間的差異更加顯著，我們認為二者試劑的檢測原理會影響到分析結果。當實驗室更換試劑廠牌時，此差異會影響醫師對於決策值的評估，因此檢驗室與臨床醫師之間應建立起針對試劑性能標準的討論機制。

This study aimed to investigate the differences in LDL-C measurements between two reagent manufacturers, Kyowa and Sekisui. The experimental results showed that LDL-C results were higher by using the Kyowa reagent than using the Sekisui reagent in both the physical examination group and the metabolic patient group, and the differences between these groups were even more pronounced. Thus, we concluded that the detection principle of the two reagents may affect the analytical results. When laboratories change reagent manufacturers, this difference reagent performance will affect physicians' evaluation of clinical decision-making value. Therefore, a mechanism between the laboratory officers and clinical physicians for discussing how to recognize reagent performance differences and their impact to the clinical decision-making value should be established.