台灣子宮內膜癌患者的流行病學與死亡率：2001-2018年之研究分析

Epidemiology and mortality among women diagnosed with endometrial cancer: an 18-year study (2001-2018) in Taiwan

在已開發國家，子宮內膜癌是最常見的婦科癌症，肥胖是其主要的一個可調整風險因素。肥胖與其他臨床變數在子宮內膜癌存活者的死亡率中具有複雜的關聯，這可能受到該疾病特有的分子變化的影響。現有數據顯示，可能存在調節這些關聯的生化途徑，但具體機制尚不清楚。本研究旨在通過結合臨床因子變化與流行病學數據，闡明子宮內膜癌患者的分子生物學與存活結果之間的關係。更深入地理解這些關聯可能會帶來更個人化的風險評估和針對性治療方案，最終改善患者的預後。

In developed countries, endometrial cancer is the most prevalent gynecological cancer, and obesity is a major modifiable risk factor. Obesity and other clinical variables have a complicated connection with mortality in endometrial cancer survivors, which is probably impacted by molecular alterations unique to the disease. The available data points to potential biochemical pathways mediating these correlations, although the specific processes are not well known. This research aims to clarify the relationships between molecular biology and survival outcomes in patients with endometrial cancer by combining biological changes with epidemiological data. A more thorough comprehension of these correlations may result in more individualized risk assessment and focused treatment plans, which would ultimately enhance patient outcomes.