芳香烴受器之配體對小鼠生殖系統之影響

Effects of Aryl Hydrocarbon Receptor Ligands on the Mouse Reproductive System

世界衛生組織將不孕症定義為一種生殖系統疾病。全世界不孕問題正在日益嚴重。主要原因包含基因遺傳、生活方式和環境因素。因此，不孕症可能與生殖細胞成熟發展過程息息相關，其中包含潛在慢性疾病或免疫調節有關。本研究將探討芳香烴受器之激活與抑制配體對生殖器官發育之影響。
芳香烴受器是一種可被配體調節的轉錄因子，介導下游毒性代謝與生物效應及免疫細胞調節，並且與雌激素受器相互影響活性。本研究以四十六隻六至八週齡Balb/C雄性與雌性小鼠給予芳香烴受器內源性激活配體Kynurenine與外源性抑制配體CH223191，分析生殖系統的組織學變化。
本研究發現芳香烴受器激活與抑制具有潛在藥理作用，進而調整精子發育與子宮組織學改變，並且預測配體可能地結合殘基位點，未來可應用於開發有效的免疫療法或個人化精準醫療暨預防保健發展。

The World Health Organization defines infertility as a disease of the reproductive system. The problem of infertility is becoming increasingly serious around the world. The main causes include genetics, lifestyle and environmental factors, as well as underlying chronic diseases or immune homeostasis. The objective of this study was to illuminate the effect of aryl hydrocarbon receptor ligands on the reproductive organs.
The aryl hydrocarbon receptor is a transcription factor that can be regulated by ligands, mediates downstream toxic metabolism, biological effects and immune tolerance, and interacts with estrogen receptors to influence their activity. Forty-six Balb/C mice, 6-8 week-old, male and female, were used in this study to administer the endogenous activating ligand Kynurenine and the exogenous inhibitory ligand CH223191 to analyze the histological changes in the reproductive system.
Results revealed that both aryl hydrocarbon receptor activation and inhibition have potential pharmacological effects, thereby adjusting sperm and uterine development according to histological examination. Furthermore, prediction of possible interaction residue sites of ligands can be applied to the development of immunotherapy or personalized precision medicine