| 英文摘要 |
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, has been applied in several neurological and psychiatric disorders. Theta burst stimulation (TBS) is a modified form of rTMS and has shown compatible effects with rTMS in the treatment of major depressive disorder. Due to its lower stimulatory intensity and shorter duration, TBS is considered more feasible than rTMS for the treatment of autistic people. Given that rTMS/TBS can modulate synaptic plasticity and excitatory/inhibitory imbalance, which are key pathological factors in autism, they may hold therapeutic potential in its treatment. In this manuscript, we report earlier studies and summarize several of our double-blinded randomized clinical trials regarding the application of rTMS/TBS in the treatment of autistic people. Various brain targets, including the dorsolateral prefrontal cortex, posterior superior temporal sulcus, and right inferior frontal gyrus, are mentioned in this manuscript. Overall, while earlier open-label trials suggested the therapeutic potential of applying rTMS/TBS in autistic people, subsequent randomized controlled trials failed to replicate these earlier promising results. Whether rTMS/TBS can effectively help autistic people remains inconclusive based on limited studies. As there has been no biological intervention established for autistic people, we eagerly anticipate further studies with larger sample sizes, double-blinded study designs, and precise study protocols that take into account individual differences. |
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