Statin用在子宮內膜癌的檢視

The role of statin use in endometrial cancer patients

Statin乃HMG-CoA抑制劑，主要作用是降低膽固醇，並能減少婦癌細胞增殖、血管生長和（或）轉移，故可為預防或輔助化學治療之用。本文討論statin在防治子宮內膜癌所顯示的論證。未來仍有需更大規模與對照組的臨床研究，並考慮不同類型statin、手術前和手術後的使用、使用時間長短，才能更明確有效的知道statin對子宮內膜癌之療效。

Statins, also known as HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) inhibitors, are a class of bioactive small molecules that eficiency reduce the levels of cholesterol. Statins may also affect full proliferation, angiogenesis and/or migration (metastasis) of gynecologic cancer cells, and play a positive role in the chemoprevention and adjuvant treatment of cancer, thus being the excellent candidates to be repurposed in oncology. In this article, we discuss the effect of the use of statins in the prevention and treatment of endometrial cancer. Future studies, including large and well-controlled clinical trials, considering the type of statin use, time of statin use prediagnosis or postdiagnosis, as well as duration of treatment are vital to validate correctly the promising effects of the use of statins in women with endometrial cancer.