英文摘要 |
This case report presents a 75-year-old male with chronic lymphocytic leukemia. He was hospitalized owing to persistent nausea and vomiting. The initial diagnosis was gastrointestinal bleeding complicated by anemia. Gastroscopy showed diffuse gastric ulcers and tumors in the gastric body, and the pathology report of the gastroscopic biopsy suggested malignant B-cell lymphoma. An abdominal CT scan was arranged, which showed multiple enlarged lymph nodes in the liver and abdominal cavity. A second gastroscopic biopsy confirmed the diagnosis of diffuse large B-cell lymphoma. The progression from chronic lymphocytic leukemia to highly malignant lymphoma is known as Richter’s syndrome. The rapid progression of the disease has a medium to high risk of survival. Therefore, we re-staged the disease, and arranged bone marrow examination, positron emission tomography, and right axillary lymph node biopsy. Approximately 1 month after the appearance of symptoms, the diagnosis was established. The patient’s symptoms were relieved after chemotherapy regimon of FCR, his condition was stable, and he was discharged from hospital. When patients present with symptoms of nausea and vomiting that do not improve after anti-ulcer drug therapy, they need to be examined by gastrointestinal endoscopy. If clinical symptoms, such as anemia accompanied by weight loss or night sweats, are reported, the possibility of cancer should be highly suspected. By taking a detailed medical history, physical examination, follow-up examinations, image examinations, or auxiliary pathological examination of biopsies as necessary, differential diagnosis can be made to confirm the diagnosis at the early stage to ensure the best timing for treatment. (Cheng Ching Medical Journal 2022; 18(2): 47-55) |