| 英文摘要 |
"Fragrances are the most common chemicals in cosmetics to which people expose every day. However, the unwantedallergic reactions such as contact dermatitis caused by direct contact with fragrances may happen. In Directive 2003/15/ECof the EU, cosmetic product containing one or more of 26 fragrance allergens must be declared on the package label. Inaddition, commission regulation (EU) 2017/1410 amending Annexes II and III of cosmetic regulation 1223/2009 restrictedfragrance chemical of methyl eugenol, and prohibited Lyral, atranol, chloroatranol to be used in cosmetic. In this study,an efficient and sensitive GCeMS method for 3 banned fragrances, 26 fragrance allergens along with restricted methyleugenol in cosmetics was established. Sample preparation by liquideliquid extraction was developed by testing varioussolvent systems to simplify traditional complex extraction methodologies. Validation of the proposed method showedgood linearities in a wide concentration ranges of 0.1e10 mg/mL. The intra-day and inter-day recoveries were between84.4 and 119% with coefficient of variation (CV) below 13.5%. The limit of quantifications (LOQs) of 27 fragrance allergenswere in the range of 2e20 mg/g. A surveillance study consisted with 82 cosmetics was conducted, among which 31products claimed fragrance-free. The results showed some fragrance-free claims were false. In the other hand, there wereseven cosmetics labeled containing Lyral, but only four were detected. The top fragrance allergens detected in thesamples were linalool, limonene, and geraniol. The analysis of fragrance allergens in cosmetics indicated that potentialcontact allergy related to these products should be considered, even though some fragrance allergens were from naturalextracts, such as oak moss absolute." |
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