Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana   全文下載

Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana

"Eight new diterpenes, 6a,7b-dihydroxyferruginol (1), 6a,7a-dihydroxyferruginol (2), 6a-hydroxyhinokiol (3), 4a-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4a-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7a-acetoxyabieta-8,12-diene-11,14-dione (7), 7a-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along withfour known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7a-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolatedfrom the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data(appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds,compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formationof LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana."