低溫常壓電漿於癌症治療、蛋白質薄膜沉積與牙科治療等醫學應用

Applying Low-temperature Atmosphericpressure Plasma to Cancer Therapy, Protein Coating, and Tooth Therapy

隨著技術發展，低溫常壓電漿開始應用於生醫領域，其具有生成活性氮氧物質、觸及率佳、副作用小、可攜帶、成本低等優點，適合應用於牙科或皮膚科等醫療。本文介紹低溫常壓電漿的三種醫療應用。第一是用於牙齒美白，效果比美白膠好且牙釉質傷害小；第二是快速蛋白質沉積用於生物晶片製程，速度比共價鍵固定快且不需使用化學藥劑；第三是肺癌肋間膜轉移治療，發現電漿可選擇性抑制肺癌細胞且對良性細胞影響不大。

In recent years, the low-temperature atmospheric-pressure plasma (LTAPP) is applied to medical applications. It has several advantages including reactive oxygen species (ROS) generation, gaseous, low side effect, portable, and cost-effective, so it is very suitable for the dental or dermatology therapy. This article introduced three LTAPP medical applications. First is for tooth bleaching, the bleaching efficacy of LTAPP is better than H2O2 jet and the harm to enamel is less. Second is aerosol-assisted atmospheric-pressure plasma deposition. It takes about 5 mins and needs no chemicals to trap protein on the substrate for biosensor fabrication. Third is applying LTAPP for management of malignant pleural effusion. The result showed that, after plasma treatment, the CL1-5 cancer cell is inhibited, while the benign cells were not significantly harmed.