鴉片類藥物引起的腸道菌叢不良在止痛耐受性中的角色

The Role of Opioid-Induced Microbial Dysbiosis in Analgesic Tolerance

鴉片類藥物對腸道菌叢組成和菌叢平衡的影響最近引起了越來越多的關注。這些鴉片類藥物引起改變被稱為鴉片類藥物引起的菌叢不良（OID），是與多種疾病以及抗傷害的耐受性的發展有關。臨床前的動物研究已經了解到腸道菌叢組成在止痛耐受性形成中的重要性，因此可能使這些方法成為減少鴉片類藥物耐受性和減少鴉片類藥物需求的新治療方法。在本文中，我們回顧了OID對耐受性發展的影響及其作為新型治療目標的潛在作用。

The influence of opioids on the composition and balance of gut microbiota have gained increased attention recently. These alterations, known as opioid-induced dysbiosis (OID), are correlated with multiple disease states and, also, the development of antinociceptive tolerance. Pre-clinical studies have recognized the importance of gut microbiome in the formation of analgesic tolerance and, therefore, make these commensals a new therapeutic subject for attenuating opioid tolerance and reducing opioid demands. In this article, we reviewed the infl uence of OID on the development of tolerance and the its potential role as a novel therapeutic target.