| 英文摘要 |
Montmorillonite (MMT) is a mineral that is capable of adsorbing bacteria due to its large specific surface area. Chitosan (CS),a biodegradable and biocompatible natural polysaccharide, has good antibacterial properties but only in an acidic medium. In thisstudy, quaternary ammonium CS (QAC) was prepared by graft polymerization of 2-[(Acryloyloxy)ethyl]trimethylammoniumchloride (AETMAC) monomers onto CS to increase the antimicrobial activity of CS in a neutral environment. Different amounts ofCS and QAC were then mixed with MMT to form CS/MMT and QAC/MMT composites, respectively. The introduction ofAETMAC into CS chains was confirmed by Fourier transform infrared spectroscopy. The X-ray diffraction analysis showed thatQAC was better able to intercalate into the interlayer of MMT than CS due to the stronger electrostatic interaction between QACand MMT. The antimicrobial test results demonstrated that the antimicrobial activity of CS was remarkably improved after graftpolymerization of AETMAC. Moreover, the QAC exhibited a broad spectrum of antimicrobial activity against Escherichia coli,Staphylococcus aureus, and Candida albicans. Additionally, QAC/MMT had higher antimicrobial ratio than CS/MMT. Theantimicrobial activity increased in proportion to the amount of QAC in QAC/MMT. Of particular note was the superiorenhancement of antibacterial activity against Staphylococcus aureus that was observed when the QAC/MMT composite weightratio was 1:10, suggesting its potential for antimicrobial applications. |
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