Taiwan’s successful pandemic response adapts to the unique challenges arising from COVID-19. Interventions include enhancing its 2003 SARS Traffic Control Bundling model to manage asymptomatic/ presymptomatic patients. Taiwan emphasized containing hospital and community-hospital-community transmission by implementing enhanced Traffic Control Bundling (eTCB) while working closely with the public to encourage community hand hygiene and facemasks. Avoiding lockdowns, Taiwan’s approach is a low intervention and effective model for countries as vaccination campaign and variants compete with each other in controlling COFVID-19 pandemic. In terms of mitigating community epidemic, Taiwan’s major government goal is to minimize pandemic impacts in the interim period between the outbreak and vaccine availability while enhancing surge capacity. We propose a layered containment strategy as an initial response based on TCB and six-sigma principles to divide administrative districts into smaller sub-districts. Each sub-district deploys one “community screening station” as the hub of the total network of the healthcare system to link between primary healthcare at the community level and isolation hospital groups. Taiwan’s example demonstrates that effective pandemic response requires a government willing and able to adapt policies and engage the population in response to changing conditions. Given the likelihood of additional COVID-pandemic waves following vaccination campaign and reopening, and the high economic costs of drastic lockdowns, the Taiwan experience can be the ideal model for pandemic responsiveness before global herd immunity is achieved.