Background and purpose: Immunocompromised and elderly patients are at increasing risk of infection by Candida, a strain of fungus that can cause bloodstream infections in the critically ill. Methods: ICU patient data collected during 2009 to 2012 by four Southern Taiwanese hospitals was used to conduct a retrospective, multicenter study on candidemia patients older than 65 years of age. Results: Patient data for 198 patients was used for anal-ysis. The mean age of all patients was 77.9. Mean Charlson comorbidity index (CCI) and APACHE II scores were 10.2 (± 3.3) and 28.1 (± 7.9), respectively. We found significantly higher rates of C. albicans candidemia in young-old patients compared to old-old patients (71.8% vs. 53.1%, P=0.008). Overall ICU and in-hospital mortality was 40.9% and 64.6%, respectively. Multivariate analysis found ICU mortality of candidemia patients to be signif-icantly associated with prior exposure to broad spectrum antibiotics (P=0.039). Patients with high CCI scores and those who had recently undergone abdominal surgery were found to be less likely to contract non-albicans candidemia. Conclusion: We found significant differences between the clinical features and species distribution of candidemia in critically ill young-old and old-old patients. Prior exposure to broad spectrum antibiotics is a risk factor for candidemia, and also significantly impacts on mortality.