Topiramate is a sulfa-derivative drug, which was used in many diseases, including seizure, migraine prophylaxis, trigeminal neuralgia, bipolar disorders, depression and weight-loss. Secondary acute angle closure glaucoma is one of the side effects of topiramate. We presented a case of 41-year-old myopic woman with acute bilateral blurred vision after taking topiramate as weight-loss drugs for ten days. Elevated intraocular pressure (IOP), increased lens thickness (LT), and decreased anterior chamber depth (ACD) were noted. After immediate discontinuation of topiramate and given ocular hypotensive medication, her IOP returned to normal and vision recovered completely. Review of the medication record is crucial, especially when acute angle closure and myopia occurred simultaneously.