Evidence Based Medicine (EBM) has become one of the most popular and effective research methods to investigate on medical-related science fields. It integrates previous researches, aiming to inspect and accomplish a deeper understanding in the already existing opinions and results. This article aims to make an approximation on understanding how to conduct EBM using meta-analysis and systematic review for academic evidences. Consequently, throughout the present article, network meta-analysis are also introduced. EBM has proofed to efficiently promote a more effective research method when obtaining scientific evidence, simultaneously improving expectations to be more practical on clinical application. Additionally -and in order to maintain the article’s liability- it was considered necessary to specify and tackle the most relevant pros and cons.