This report describes the nursing care experience of a patient diagnosed with Guillain-Barre syndrome who suffers from sudden limb weakness due to acute peripheral neuropathy. The period of nursing care was from March 24, 2019 to March 31, 2019. We applied the Gordon’s 11 Functional Health Patterns Assessment Guide, care, interviews, observation, and review medical records to assess the nursing problem. The major health issues identified included impaired physical mobility, risk of infection and anxiety. During the period of care, the author and physical therapist conducted daily physical therapy to assist in changing positions and taught joint exercises to enhance physical activity functions. By observing the catheter insertion site and surrounding skin condition, we taught catheter care and infection prevention methods, including daily catheter care using an aseptic technique, to avoid infections. Through caring, listening, and encouraging expression, we used the family support system and home furnishings to create a warm environment. We further taught relaxation skills to reduce the sense of uncertainty and anxiety and promote a positive response to facing disease progression. We recommend developing mobile phone application software for rehabilitation exercises in the future. Such software could allow patients to effectively and correctly perform rehabilitation exercises when no physical therapist is present during home care.