A 60-year-old women suffered from pathologic fracture of right femur and received open reduction and internal fixation. The pathologic report of bone specimen was metastatic carcinoma. After tumor survey, she received diagnostic dilatation and curettage and a diagnosis of endometrial endometrioid carcinoma (EEC) was made. PET scan showed multiple metastases including bone, brain, and lung metastases. A stage IVB endometrial EEC was impressed. The patient refused further chemotherapy and radiotherapy. She passed away due to progression of brain metastases 3 months after operation. Bone metastases from endometrial carcinoma is an unusual condition. It indicates delayed of diagnosis and is associated with poor outcome. A bone biopsy with immunohistochemical staining may help in the differential diagnosis of the primary tumor site.
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