Purpose: To explore the differences of main death cause between the home death group and the country. Methods: A retrospective case analysis was used to analyze the main causes of 774 deaths at home in Yilan County from 2017 to 2019. Results: The top ten causes of home death are: 1. Heart disease 2. Malignant neoplasms 3. Senility 4. Pneumonia 5. Chron¬ic lower respiratory tract disease 6. Cerebrovascular disease 7. Nephritis and nephropathy 8. Hypertensive disease 9. Diabetes 10. Chronic hepatitis, cirrhosis. Among the top ten causes of death, the highest average death age is due to senility: 85.71, and the Minimum average death age is due to chronic hepatitis, cirrhosis: only 64.11. CONCLUSION: Heart disease is the largest cause of home death, and senility has replaced accidental death and is an impor¬tant cause of home death.