Acute respiratory distress syndrome (ARDS) is a common disease in the intensive care unit, and its mortality rate lies between 40.3~46.1%. A research in 2013 revealed that the mortality rate of severe ARDS patients who take prone position treatment is 24%. Therefore, the clinical application of prone positioning is increasing rapidly nowadays. The principle of prone position treatment for severe ARDS is to increase use of effective alveoli and to decrease pressure of heart and mediastinum through turning prone. This leads to more blood perfusion to effective alveoli and an increase in ventilation flow ratio. Also, it improves oxygenation by promoting mechanisms such as the discharge of sputum. Through this article, we hope clinical nurses become aware that there are several nursing operations to notice in different stages of prone positioning (preparation, execution, and completion period). Precautions include preventing respiratory duct obstruction, protecting high risk areas like pasting adhesive foam dressing on bone protrusion, and maintaining functional form of catheter surveillance and drainage tube. The abovementioned matters help alleviate patients’ concerns during the whole prone period, get rid of the occurrence of complications, lower the mortality rate, and aid patients’ recovery. These details not only exert the specialty of our nursing skills, but also offer patients with the best service