A 1 year 4 month-old boy had dysphagia and had received nasogastric tube feeding since birth. Medical history revealed that he was born preterm with a very low birth weight. In addition, he had four-limb weakness, cognition, language and motor developmental delay, and a growth curve below 3%. He was referred by local medical doctor and brought to our Chinese medical outpatient department for acupuncture treatment. Shuigou (GV26), twelve-well points, and Zusanli (ST36) were used for acupuncture therapy twice a week. After thirteen treatment sessions, the nasogastric tube was removed, and the patient began to tolerate oral feeding. Furthermore, evaluation with the Bayley Scale of Infant Development-III revealed that his cognition and motor development had improved after four months of treatment. His muscle power also improved. He gradually learned to crawl and stand; he could walk independently after six months of treatment. In this case, he was diagnosed with five kinds of retardations and flaccidity. Our report reveals the benefits of acupuncture combined with early intervention for the treatment of dysphagia and developmental delay in preterm infants before two years old.