核醫藥物半衰期與血管內皮細胞損傷之間的相關性

Interrelation between half-life of nuclear medicine and damage of vascular endothelial cel

方法：將兩個慣性感測元件固定於受試者的膝關節和外踝搭配遠程監控系統以測量其開放動力鏈運動數據，藉由分析兩個不同位置的慣性感測元件的同步角速資料將運動開放動力鏈運動作分類。

 

Objective: Nuclear medical examination is to use agents labeled on unstable radioactive seeds. Then, these tracer agents are injected into the patient’s body or absorbed orally. According to the characteristics of various tracer agents distributed to some specific tested organs, the extremely small amount of gamma rays emitted by these unstable nuclear seeds can be taken by radiological detection instrument for diagnosis. According to the previous literature and clinical studies, the quality of nuclear medicine is a relatively balanced role in the science of nuclear imaging. This research puts forward a hypothesis is: when radioactive tracer injection organisms, after a half-life, two half-life and after 24 hours, vascular endothelial cells in nuclear medicine retention, whether can produce damage effect. Methods: Experiments were conducted via the rat femoral vein injection dye agent Evans blue (EB), which was followed by the injection of the same concentration, a different dose（0.2 mCi, 1 mCi and 5 mCi）of radioisotope (free 99mTc) and then the EB in the tissue to measure the vascular permeability. Results: The longer the retention time, the vessels present a very slight leakage reaction. In addition, according to the colloid carbon leakage markers and the histomorphological experiments, the experimental results of vascular leakage showed that the experimental group showed a very small amount of colloid carbon leakage, and the red blood cells were only slightly infiltrated. However, the results showed no significant difference with the saline injection (control group). In terms of immunohistochemical staining, the presence of nitrotyrosine can serve as an indicator. The experimental results showed that the longer the residence time of nuclear drugs, the darker the color of nitrotyrosine. Taken together, these results suggest that the longer the exposure to radiation, the more NO is produced, or perhaps the endothelial cells are destroyed and the leakage increases. The conclusion of this study is that the excessive production of NO is involved in the vascular injury and leakage caused by radioactive nucleation seeds in vivo.