Returning medications is a necessary work, but it consumes significant amounts of time and resources. This study aims to improve the efficiency of returning medications to pharmacies in the hospital setting. In order to decrease the workload of pharmacists involved in the medication returning process, we made some action plans and expect that the new process can improve work efficiency. After implementation of the correction strategies, the total time to process the returned medications can be reduced by 40 minutes/day. Overall, the time needed for the process was reduced by 36.4%, the accuracy of records on returning medications was improved, and the pharmacist working satisfaction was increased. The efficiency of managing returned medication improved after this study, and the time redistributed to clinical pharmacy services increased, thus enhancing the medication safety and quality of the patient care process.