Infertility is defined by the failure to achieve a clinical pregnancy after having regular unprotected sex for over 12 months. The World Health Organization (WHO) estimates that about 8-12% of couples have experienced infertility. Late marriage and advanced reproductive age have become trends. Thus, the prevalence of infertility in Taiwan is as high as 15%, of which male factors account for 20 - 70%, while female factors account for about 60-70%. Poor quality of semen is the most important factor in male infertility. However, the pathogenesis of sperm quality is still not known. Various treatments or nutrients have been shown to be effective in some patients, but are still ineffective for many. For the above reason, about 30-40% of patients seek alternative treatments such as acupuncture and Chinese medicine. The literature of Traditional Chinese Medicine shows that poor quality of male sperm results from congenital deficiency, overwork, excessive sexual exhaustion, improper diet, affect-mind dissatisfaction, etc. The Traditional Chinese Medicine pathogenesis more commonly points to kidney vacuity, spleen vacuity, deficiency of vital energy, blood deficiency,heart and kidney failure to interact, dampness-phlegm syndrome, Qi stagnation, etc. This article explores the therapeutic effect of traditional Chinese medicine on male infertility. Taking a male infertility patient with the abnormal quality of sperm as an example, Chinese medicine treatment combined with semen analysis can successfully improve the quality of sperm in patients and lead to successful conception.