Opioid substances under strict regulation are the key component of clinical therapy ranging from regular post-procedure pain relieve to intractable cancer pain management. However, the abuse and uncontrolled black market transaction would pose a significant impact on society and damage to patient health. Even in professional medical practice, under-trained professions who prescribed opioid substance to a patient without formally and thoroughly evaluate the situation of the patient might also pose harm to patients. Furthermore, the un-compliance of the regulation of prescribing controlled substances might face a penalty from criminal laws. In this article, briefly introduce the liability of prescriber and other healthcare professional, possible penalties and guidance on formal procedures to evaluate the need of validity of controlled substance.