This article explored the nursing experience of a 49-year-old hemodialysis patient who has undergone dialysis for 31 years and has recently suffered a psychological adjustment disorder due to the loss of his girlfriend. During the nursing period, from July 18, 2016 to September 16, 2016, the “Roy Adaptation Model” was used as the assessment tool to collect the data of the subjects from the observation, talks, physical assessment, listening, objective information, it was established that the patient suffered from “excess fluid volume,” “nutritional imbalance / less than the body needs” and “barriers to adjustment” issues. During the care period, the author accompanied the process of grief, actively showed care, listened to the feelings of the patient, provided appropriate nursing care measures, made food records and discussed water control with case, thereby improving the control of body fluid volume and hypotension due to dialysis, employed the use of Mini Nutritional Assessment (MNA) scale to assess the patient’s nutritional status, understand diet management methods to correct malnutrition, and provided encouragement for him to speak out his feelings and thoughts; used listening to music and religious intervention to alleviate the negative emotions, to enable the patient to adapt to life without his girlfriend, to focus in his life, to improve his ability of self-care and his quality of life.