This article explores the case of a 36-year-old woman with end-stage diabetic nephropathy who, after six years of receiving kidney transplantation, is in need of for hemodialysis again due to inadequate self-health care. The nursing period was from April 1 to May 22, 2016, when the patient had weekly dialysis at the hospital. Orem nursing theory was used as assessment guideline, after collecting and analyzing the data through physical assessment, observation, interviews and patient records, the main nursing problems were confirmed to be: excessive body fluid volume, lack of knowledge and social isolation. In the care process, through the nursing professionals and the collaboration of the medical teams, after reviewing the patient’s daily diet records and habits, used nursing measures to teach the patient about proper medication taking and healthy eating, guided her to establish a healthy daily eating and medicating routine that would enable the patient to independently implement liquid intake control and prevent hyperphosphatemia; psychologically, encouraged her to express her feelings and worries, use the support system in the hospital and at home, encouraged her to take part in activities to improve self-worth and expand her social circle, leading her to live positively with dialysis while waiting for the opportunity of a new kidney transplant.