Wholism is the basic characteristics of TCM Psychology, which put spirit and psychological phenomenon in the natural, social and physical environment’s extensive connection and mutual influence. Wholism has kept close contact with Mind and Body. It is viewed as a part of the whole, which is subordinate to nature and society at the next level. We can see emotion, five organs related to mental activities, perception and other mental phenomena from the relationship of Mind-Body. We can see the “wisdow” , “cognitive”, thought, anxiety, ying exhaustion, seminal loss and other phenomena from the relationship of psychology-society. The relationship of psychology-society has presented emotion, mental state and other general phenomenon, and zhenren, zhiren, shengren, xianren and other ideal personality, which is closer to the law of nature. Wholism of TCM Psychology can be used to guide treatment based on syndrome differentiation, psychotherapy, psychological preservation of health and so on.