Purpose: To investigate the effect of laser acupuncture on hemodialysis patients with refractory uremic pruritus. Method: In a triple blinded randomized controlled trial, 20 patients treated with laser acupuncture, 18 patients received sham laser acupuncture. Each patient received 40 seconds treatment for each acupuncture point on bilateral LI11 and HT7 three sessions per week for four weeks. The visual analogue scale (VAS) and pruritus score were evaluated before, after and 4 weeks after treatments. Result: Both laser acupuncture and sham laser acupuncture group showed no difference on VAS and pruritus score before, after and 4 weeks after treatments. No subject had any adverse reaction. Conclusion: The effect of laser acupuncture treatment using LI11 and HT7 was not significantly different compared to sham laser acupuncture on refractory uremic pruritus in hemodialysis patients.