This article describes the nursing care experience of caring for a 36-year-old female patient with Systemic Lupus Erythematosus. The intubated patient with respiratory failure was successfully weaned from the ventilator in the intensive care unit. The nursing period was from November 26, 2016 to December 26. With the Gordon’s 11 Functional Health Patterns assessment tool, the author collected data through direct patient care, patient observation, patient interview, and medical chart review. The three identified major health problems were an ineffective breathing pattern , potential risk of infection, and anxiety. With increased respiratory muscle strength through specific exercises, the respiratory pattern improved. We implemented Bundle care to prevent infection and reduce the complication rate. The team focused on the patient’s feelings, built a good therapeutic relationship, and reduced her anxiety and difficulty with breathing. With a multidisciplinary care model, we drew up a care plan and provided individual nursing intervention. The patient accommodated herself to the physical activities and mental situation well. The author hopes to share this nursing experience with those who will take care of patients in similar situations in the future.