醫用直線加速器照射引起視覺閃光感受之研究

Research on Visual Flash Sensation Caused by Medical Linear Accelerator Irradiation

在接受醫用直線加速器治療的病患，常會遇到患者主動反應有看到閃光（light flashes）的現象。本研究希望透過問卷調查與患者治療時的反應，找出閃光與放射 治療的相關，以釐清是否為幻視（phosphenes）的可能。從 2016 年 11 月至 2017年3月，總共收集 73 位腦或頭頸癌患者，使用 6 或 10 MV 的光子或 6 MeV 電子進 行照射。放射治療後給予問卷與訪談，根據問卷回溯患者治療計畫系統，利用 SPSS統計軟體分析樣本數據。統計變數分析中發現，患者的年齡在 65 歲以下、射束有 照射到視覺路徑、視網膜單次分次劑量這些變數的視覺感受機率越高，統計學上（p<0.05）均有顯著意義，以上這些變數均是可能影響視覺感受的因素。

 

Some patients who underwent radiation therapy (RT) using medical linear accelerator reported experiencing a light flash sensation. The purpose of this study is to analyze the possible reasons between the flash feelings and RT or rule out the possibilities of phosphenes. Seventy-three patients who underwent head & neck or brain RT were recruited for this study. Twenty-three subjects were excluded. By analyzing data from two double energy medical linear accelerators, all subjects received 6 or 10 MV X-ray, or 6 MeV electron beam irradiation. The radiation dose ranged from 400 to 1600 MU/min. All subjects were surveyed after RT. Data was analyzed by SPSS. Statistical significances were observed among the age, beam to visual pathway, and single fraction retina dose (p<0.05). The causes of this phenomenon are very complicated. Variables possibly include age, whether the beam goes through the visual pathway, retina dosage, single fraction dose and other factors.