The introduction of artificial intelligence into medical technology will turn it into precision medicine. With the evolution of the medical behaviors, the role of the National Health Insurance Department have been expanded to include setting up a precise medical environment. Through the payment and management measures, the medical community is guided to take better care of people’s health with better medical quality. To use NHI medical data as the material for the development of precision medicine, the issue of personal information protection should be highly regarded. The medical related acts need to be updated. The “de-identification” seems to be the most feasible strategy. NHI will also provide the necessary medical information through the “NHI MediCloud System,” in order to make ends meet for personal information protection and quality of medical care.