Because of rapid change of the world, the way of learning has been affected and innovated. Learners do not passively receive knowledge from school, but also actively construct knowledge by themselves. It is a critical issue that students should develop self-directed learning abilities to acquire knowledge. The purpose of this article is to introduce a evidence-based reading instruction model that facilitate students’ comprehension and learning. This instruction model focuses on three strategies, including text structure, inference-making and comprehension monitoring and provide explicit teaching guidelines. We hope that teachers employ this model and foster students reading and self-directed learning abilities to face the challenging future.