乙肝病毒標誌調查在乙肝疫苗政策三十年後

Survey of HBV Markers after 30 Years of Vaccination Policy

根據施打B肝疫苗政策之不同，以羅氏公司Roche e601儀器分析病人體內HBsAg、anti-HBs、HBeAg及anti-HBc的情形及探討anti-HBs低下者是否需再追加注射B肝疫苗？結果顯示在1984至1985年出生者其HBsAg、anti-HBs、HBeAg及anti-HBc分別為5.8％、77.3％、7.4％及17.4％而1986至2013年出生者分別為2.1％、55.3％、6.1％及5.6％。台灣衛生福利部疾病管制署的專家建議，B型肝炎感染高危險群，如未曾感染B型肝炎病毒且經檢驗為B型肝炎病毒表面抗體陰性者，建議接種3劑B型肝炎疫苗，以降低感染風險；但曾於嬰幼兒時期接種過B型肝炎疫苗者，可採追加1劑疫苗，1個月後再抽血檢驗，如表面抗體仍為陰性（＜10mIU/ml），可依「0-1-6個月」之時程接續完成。

To analyze the markers of HBsAg, anti-HBs, HBeAg and anti-HBc within patients born under different HBV vaccination policy via Roche e601 and explore whether it is necessary to booster vaccination for those patients with low anti-HBs. Results: The positive rates of HBsAg, anti-HBs, HBeAg and anti-HBc of those born in 1984 and 1985 are 5.8%, 77.3%, 7.4%, and 17.4% respectively. On the other hand, the positive rates of these markers of those born from 1986 to 2013 are 2.1%, 55.3%, 6.1%, and 5.6% respectively. Suggestions: Experts of Centers for Disease Control, Ministry of Health and Welfare suggested that people who are at high risk of HBV infection, if negative for HBsAg and anti-HBs, should receive three doses of vaccination to reduce the risk of infection. Moreover, one shot of vaccine can be added to those who had received vaccination at their infant stage. If anti-HBs is still negative (< 10mIU/mI) after one month, three- dose of vaccination on a 0-1-6 month schedule can be applied in these subjects.