Andrographis paniculata (Burm. f) Nees, commonly recognized as ‘king of bitters’, is an herbaceous plant of the Family of Acanthaceae used extensively in Southeast Asia, In-dia, Thailand and Malaysia for the treatment of sore throat, fluand upper respiratory tract infections. This plant contains the pharmacologically important chemical constituent an-drographolide. Andrographolide has been offered wide variety of pharmacological activities such as anti-inflmmatory, antibacterial, antitumor, antidiabetic, anti-HIV, anti-feedant, and antivirus. Cardiovascular diseases are still the leading cause of death worldwide. Impaired endothelial function followed by inflammationof the vessel wall leads to atherosclerotic le-sion formation that causes myocardial infarction and stroke. Due to the rising age of the population, the incidence of heart failure is further increasing. Thus, the increase in risk fac-tor burden by age and metabolic diseases expands the incidence for vascular and cardiac diseases and provides a challenge for developing efficienttreatments. Therefore, this review aimed to provide the evidence-based information from the existing literature about the plant Andrographis paniculata and its compound andrographolide for the treatment of cardiovas-cular diseases.