Six theories of endometriosis have been proposed until now, but the real mechanism is unknown. This study aimed to explore cytokine-related immune responses of traditional herb prescription in endometriosis. We would summarize immunological aspects of endometriosis and immune-related mechanisms of prescription for endometriosis in Taiwan.
By way of regulating inflammatory pathway to induce adhesion and invasion, angiogenesis, and proliferation, immune cells could help endometriosis lesions implantation and survival.
Based on differential diagnosis and treatment of Chinese medicines, activation of blood circulation and elimination of blood stasis were as the main method of treatment. It could block local angiogenesis and lead ectopic lesion to atrophy. Gui-Zhi-Fu-Ling-Wan, Xue-Fu-Zhu-Yu-Tang and Shao-Fu-Zhu-Yu-Tang were commonly used prescriptions. In addition, reinforcement of kidney and spleen to promote cellular immunity may be as an alternative treatment strategy. For example, Gui-Shen-Wan, Zuo-Gui-Wan and Liu-Jun-Zi-Tang were the common prescriptions. According to the other symptoms and signs, Xiao-Chai-Hu-Tang, Long-Dan-Xie-Gan-Tang and Wen-Jing-Tang would be used to treat endometrisis. The present study would suggest that endometriosis caused by immune dysfunction could be restored and improved by replenishing method.