期刊連結：http://www.gouthyperuricemia.org

Objective: To explore the effect on gout recurrence after using amoxicillin or cephalexin in gout patients.

Methods: We designed this study as a retrospective cohort study. Gout patients greater than or equal to 20 years old were extracted from outpatients database which was provided by the National Health Insurance Research Database (NHIRD) of Taiwan. Gout patients were diagnosed using the International Classification of Diseases Ninth Revision (ICD-9) code 274 that coded for more than five times and with first gout diagnosis date after January 2001 to ensure the gout attack was first diagnosed. Two prescribed medicines, such as amoxicillin and cephalexin, were recorded for those using medication for more than seven days to observe medical visit frequency in gout patients.

Results: A total of 5,966 amoxicillin or cephalexin users were included in this study from 21,220 male gout patients. The results showed 3.79% and 5.21% of gout patients who used amoxicillin and cephalexin had visiting gout treatments during the next week, respectively. The relative risk (RR) for amoxicillin users was 0.73 after adjustment of age (95% CI=0.61-0.86, p<0.001) within first week while compared to those that used cephalexin. Furthermore, those using amoxicillin have the same significantly protective association during next four weeks as the result of first week (RR=0.87, 95% CI=0.79-0.96, p=0.005).

Conclusion: Amoxicillin reduces gout recurrence within four weeks for those taking amoxicillin for more than seven days compared to cephalexin users.