期刊連結：http://www.gouthyperuricemia.com
Objective: The aim of the present study is to investigate whether the rs1145317 polymorphism of methyl-CpG-binding domain protein 2 (MBD2) gene has any association with primary gouty arthritis in Chinese Han population.
Methods: The MBD2 gene rs1145317 polymorphism was genotyped by real-time polymerase chain reaction with 5’exonuclease TaqManTM technology from 485 primary gouty arthritis patients and 485 health controls. The distributions of genotypic and allelic frequencies were analyzed using the SHEsis online software.
Results: The numbers and frequencies of AA, AG and GG genotypes were 113, 225 and 147 (23.29%, 46.39% and 30.31%), respectively, among the gout group, while there were 114, 233 and 138 (23.51%, 48.04% and 28.45%) in the control group. The results showed that no statistical differences were detected in the genotype distribution of MBD2 gene rs1145317 between the cases and controls (χ2=0.43; P=0.807). The allele frequencies of A and G in gout group (46.45%, 53.51%) and control group (47.52%, 52.47%) were not significantly different (χ2=0.21; P=0.649).
Conclusion: These findings suggest that MBD2 gene rs1145317 might not be associated with gouty arthritis in Chinese Han population. Therefore, this single nucleotide polymorphism (SNP) might not be used as a risk factor to predict the susceptibility to gouty arthritis.
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