Chinese Medicine (CM) conventionally described Zang organs according to the Zangfu manifestation theory. Current CM studies demonstrated that myocardial contractile strength and efficiency may represent Zang Heart-Qi. While it illustrates how in CM the Zang Heart directs circulation, little has been shown how thereby it carries the spirit, as CM describes it houses Shen. The controversy as to whether the brain or the heart directs (‘governs’) the Shen mastery still remains unsolved, and diverges CM thoughts. This paper reviews how the Zang Heart could mean the same anatomical organ but with an added dimension. Re-inclusion of its connections up to the cortical-autonomic system would help to restore the anatomical functional tie. The one Cortical-autonomic-medullary-heart Complex may be taken as the Zang Heart. Its lower medulla-autonomic-heart system reflexively stabilizes the circulation while connections up the higher cortical autonomous system provides regulation for situational circulatory responses, motive or emotive as necessary, likened to its CM-described capacity to transform Shen (into different modes of mental mastery). Zang Xiang (external manifestations) may be expressed as functional features of that one structure as it integrates emotional and cognitive components of the mind with autonomic cardiovascular control, related with intestinal absorption for capacity of body perfusion, and its connection to the whole central nervous system and the body, as neural and circulatory networks evolve together with repeated remodeling since development. Remodeling of their interactions produces patterned responses to stimuli or stress, so that perfusion and nervous activity can be in balance and matched during endeavors or actions. These mechanisms together with neuroendocrinal interactions with the thermal regulation would work for perfusion needs so that, when working well to adapt to the environment, the Heart synchronizes with all organs and the whole works with mastery and efficiency, in a state demonstrated as psychophysiological coherence with the whole body in optimal function: analogous to CM describing that "the Heart holds the office of sovereign, whence the bright spirit emanates”. There are evidences that information and perfusional elements go hand in hand. From reviewing mind-body interactions remodeled during development, it is found that the tone and dynamics of the whole, in stabilizing circulation and perfusion during support of endeavors and performance, provide mechanisms to adaptations to face life. These correspond well with the described Zang Heart, and meet its essential meaning more closely than previous models, eliminating the controversy over the brain-heart split. This paper illustrates for the first time in CM literature how the mind-body, perfusion, brain-heart, body heat, temperament, and climatic thermal environment can interact and influence each other, just like what is observed in Nei Jing and supported with current research literature. This anatomico-functional model can better interpret CM literature and be easily understood by current science.