背景與目的：代謝症候群增加心血管疾病及糖尿病發生的危險，對成年男性生殖能力的影響的了解有限。本研究之目的探討謝症候群與男性生殖力之間的相關性。方法：以病歷回顧法，對2008-2013年六年期間在一所醫院接受健康檢查的男性的資料，分析代謝症候群組成因子與男性精液品質的相關性。結果：從360位健康檢查個案的檢查資料分析，發現代謝症候群與精液品質的精液量(volume)、精蟲濃度(concentration)、精蟲活動力(motility)無關，在調整年齡、吸菸、喝酒、高血壓、糖尿病等藥物影響後，患有代謝症候群個案的精蟲正常型態百分比較非代謝症候群者低，且具統計學上顯著差異。與無吸菸或無飲酒者比較，吸菸者的精液量較少，有喝酒者精蟲正常型態百分比較高，但精蟲濃度、活動力或精液量則無差異。結論：代謝症候群可能減少精液中精蟲正常型態比例，影響男性生殖力。吸菸亦影響精液的品質，有代謝症候群的男性如能控制三高及戒菸，可能有助改善其生殖力。

Background and Purpose: Metabolic syndrome, a disorder of energy utilization and storage, has been found to increase the risk of developing cardiovascular disease and diabetes, yet the adverse effects of metabolic syndrome on male fertility have remained understudied. The study aimed accordingly to explore the associations between metabolic syndrome and male fertility. Methods: Health examination data of 360 male subjects during the six-year period from January 1, 2008 to December 31, 2013 were collected and examined using retrospective chart review. After the removal of personally identifiable information, statistical analysis was performed to trace the links between the components of metabolic syndrome, the factors affecting the syndrome (e.g. age, height, body weight) and semen quality. Results: In terms of semen volume, concentration and motility, no significant difference was observed between subjects with/without metabolic syndrome. However, after adjusting for age, tobacco and alcohol consumption, and use of medicine for hypertension and/or diabetes, the study obtained the statistically significant result that the percentage of sperm normal morphology was lower in the group of subjects with metabolic syndrome. While showing no significant influence on semen concentration, motility and morphology, tobacco consumption emerged to be negatively associated with semen volume. Alcohol consumption, on the other hand, was found to affect sperm morphology. Conclusion: Male subjects with metabolic syndrome demonstrated a lower percentage of sperm normal morphology. Tobacco consumption adversely affected sperm quality. Men with metabolic syndrome may improve their fertility by quitting smoking.