This subject of this article was a hemodialysis patient who underwent amputation of his left first to third toes due to peripheral arterial occlusive disease (PAOD). The author evaluated the patient through physical assessment, observation, nursing care and communication between November 5 and December 14, 2012. The author worked with the caregiver and used all available resources in order to build up trust with the patient. The report found out that wound pain after the amputation forced the patient to change his eating and sleeping habits. As he also needed his wife’s help with daily activities and was economically dependent on his son, the patient became clinically depressed. In this case, there were some key issues including acute pain, inadequate nutritional intake and hopelessness. During the care process, the author actively engaged with the patient and established a good nurse-patient relationship. Pain relief techniques were used so that the patient felt less pain and discomfort with the amputation limb. The author also informed the patients wife on he importance of a high protein diet. A high-protein diet key ring was crafted to provide the patients wife with a reference for grocery shopping. By also instructing the wife on changing her method of cooking, this helped improve the patients nutritional intake and raised his albumin level. Gradually, family interactions and assisted care helped the patient emerge from the pit of despair and adapt to the post-amputation lifestyle. The patient was also given guidance on finding his own value, rebuilding a positive self-image and accepting his life.