This study aimed to evaluate the efficiency of nursing education for improving self-care behaviors in patients with stage 3 chronic kidney disease. Such patients usually lacked adequate recognition of the diseases and nursing education. Insufficient knowledge prevented the patients from exhibiting proper self-care behaviors and limited the efficacy of nursing education in preventing kidney disease progression. These phenomena motivated the authors to conduct this project. After careful investigation, nursing staff found that poor education tools, inadequate teaching skills, and inappropriate environments were the three major causes of inefficient health education. By reorganizing nursing education tools and teaching methods, performing teaching assessments, and improving the teaching environment, patient satisfaction with “chronic kidney disease education courses” increased from 70% to 89.4%; the score in “kidney health knowledge” increased from 27.1 to 98.6; and the score in “self-care behavior” increased from 2.6 to 3.2. These results proved that individualized patient-focused nursing education may improve self-care behaviors and quality of nursing care among patients with stage 3 chronic kidney disease.