Depression for End stage renal disease (ESRD) patients is not a new issue, but is a most common issue of emotional, psychosocial, and psychiatric problems, and comprehensive impact for patient’s physical function. The prevalence of depression among ESRD patients received alterative therapy are 33.3% to 78.8 % for hemodialysis, 19% to 51.5% for peritoneal dialysis, and 20% to 45% for renal transplantation. For such high depression prevalence, nurses of nephrologic should provide interventions, such as decline patient’s uncertainty level, appropriate social support, exercise training protocol, and musical therapy etc. to diminish depression and improve patients quality of life.