This 24 years old female suffered motorcycle traffic accident and led to loss of consciousness due to severe traumatic brain injury. In ER, the Glasgow coma scale was E1V1M1 then she was admitted to our SICU for further management. At the 4th day of admission, the Chinese Medicine was consulted and then the Chinese herbal treatment was started. After 21 days of integrated treatment, the patient was successfully extubation and transferred to general ward care. The scalp acupuncture was combined for later treatment and also got well recover. It provides us a strong experience of early intervention with integrated Chinese and Western medicine for severe traumatic brain injury.