The case report described the nursing experience of caring a patient with amyotrophic lateral sclerosis (ALS) complicated with respiratory muscle weakness induced pulmonary complications. The nursing care duration was from April 16 to May 10, 2013. The Roy Adaptation Model was used as the assessment framework. The patient’s health problems were identified as follows: ineffective airway clearance, hyperthermia, and hopelessness. The author encouraged the patient to express his feelings and concerns in order to solve the patient’s nursing problems. The author also enhanced the patient’s social support system and assisted the patient in exploring the meaning of his life and validating the value of his existence. In addition, the nursing interventions included providing chest physical care, teaching deep breath skill, and performing manual abdominal thrust to improve sputum cleaning, and providing fever nursing care to improve comfort level. The individual nursing interventions in this article could serve as a reference for caring ALS patients in the future.