The interdialytic weight gain less than 5% of dry weight for the hemodialysis patients is thought to be important in the prevention of interdialytic hypertension or intradialytic hypotension. The purpose of this project was to control the interdialytic weight gain less than 5% of dry weight for the hemodialysis patients. The resolutions included establishing medical brochures for fluid control, displaying posters on health bulletin board, creating standard nursing guidelines with regard to health education for hemodialysis care, providing in-service education program, holding medical conferences with hemodialysis patients, and assessing dry weight with body composition monitor. The results showed that the percentage of patients with 5% or more of interdialytic dry weight dropped from 37.26% to 19.67%, the percetage of patients with pre-dialytic hypertension (>150/90mmHg) fell from 17.72% to 15.09%, and the percentage of patients with intradialytic complications decreased from 20.18% to 10.36%. The project has provided successful example about standardize clinical nursing care protocol for the care provider. We want to share this experience to other hemodialytic units as a guide to improve their quality of care.