Identification of the relationship between hyperuricemia and metabolic syndrome in Chinese people

期刊連結：http://www.gouthyperuricemia.com

Objective
We did this study in order to investigate the relationship between hyperuricemia and the prevalence of metabolic syndrome.
Methods
3879 patients (age 18 to 74, 1708 male) living in the villages in Baqiao County in Gaoyou district filled out a general questionnaire and all of the anthropometric and biochemical measurements were performed by trained physician. Blood levels of biochemical parameters were also measured after a fasting period of at least 12 hours. In this study we adopted the International Diabetes Federation (IDF) 2005 criteria to diagnose metabolic syndrome.
Results
Data showed that there was a significant difference in age, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist, waist-to-hip ratio (WHR), high-density lipoprotein (HDL), fasting C-P, Metsuda Index, HbA1c, serum uric acid (SUA), prevalence of metabolic syndrome (MS) (P<0.001) and triglyceride (TG) (P=0.003) in different gender. The prevalence of both hypertension and MS increased significantly (hypertension frequency is 33.90%, 40.61%, 51.70% and 62.98% respectively, and MS frequency is 19.32%, 23.53%, 27.38% and 35.89% respectively) from the first to the fourth quartile of SUA concentration(P<0.001). Furthermore, some metabolic biomarkers, such as blood pressure, serum lipid, BMI, waist, WHR, Metsuda index, HbA1c, fasting insulin and C peptide also increased significantly in different SUA concentration groups. Binary logistic regression showed that SUA concentration was an independent risk factor for the prevalence of MS.
Conclusion
Hyperuricemia was strongly associated with the prevalence of MS.