Comparison of hyperuricemia prevalence in normal glucose tolerance subjects and type 2 diabetes patients in a Chinese population

期刊連結：http://www.gouthyperuricemia.com Objective The prevalence of hyperuricemia was reported to be high in patients with type 2 diabetes (T2D) and varied across different populations. In the current study, we aimed to assess the prevalence of hyperuricemia in a Chinese population. Methods We recruited a total of 4,221 participants, comprising 1,892 T2D patients and 2,329 subjects with normal glucose tolerance (NGT). Uric acid related traits were extensively measured for all participants. Results The overall prevalence of hyperuricemia was 11.16% in NGT subjects and 17.02% in T2D patients. In females, the prevalence of hyperuricemia was significantly higher in T2D patients than in those with NGT (20.39% vs. 7.63%, p<0.001). The opposite relationship appeared in males as the prevalence of hyperuricemia showed a tendency to be higher in NGT subjects than in T2D patients (17.05% vs. 13.88%, p=0.059). Then we assessed the prevalence of hyperuricemia stratified by age in both NGT subjects and T2D patients. The results showed that for females <55 years old, the prevalence of hyperuricemia was significantly higher in T2D patients than in those with NGT (p<0.001 when age <45 and p=0.004 when 45≤age<55). While in males, there is an obvious lower prevalence in T2D patients than in those with NGT (p<0.001 when 45≤age<55 and p=0.017 when 55≤age<65). Conclusion Hyperuricemia is prevalent in Chinese T2D patients and the age-associated prevalence of hyperuricemia was significantly high in females. Therefore, strategies to prevent and treat hyperuricemia in T2D patients are urgently needed in order to stem this national pandemic.